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   Whether through injury or simple wear and tear, the skin’s integrity and function can be easily compromised. Although this impacts billions of people worldwide, little is known about how to prevent skin degeneration. The Harvard Stem Cell Institute (HSCI) Skin Program is committed to understanding why skin sometimes fails to heal or forms scars, as well as why skin inevitably becomes thin, fragile, and wrinkled with age. The Skin Program’s ultimate goal is to identify new therapies for skin regeneration and rejuvenation. How We Heal Wound healing is a major problem for many older individuals. Furthermore, chronic, non-healing skin ulcers are a major source of health care costs and patient morbidity and mortality. Human skin repairs itself slowly, via the formation of contractile scars which may cause dysfunction. In contrast, the axolotl salamander can readily regrow a severed limb, the spiny mouse has densely haired skin that heals with remarkable speed, and the skin of the growing